ABSTRACT
To Assess the circulating Biochemical, Heamatological and Oxidative Stress Markers in Females using Contraceptives from Punjab, Pakistan. Study Design: Case Control Study Place and Duration of Study: This study was carried out at the Gynae Units of Jinnah Hospital Lahore from January, 201 1 to December 201 1. Materials and Methods: Two injectable contraceptives [Depo-Medroxyprogesterone and NorethisteroneEnantate] and Oral contraceptive pills [COCs] were administered in females of reproductive age, the oxidative and nitrosative stress biomarkers [Malondialdehyde, Superoxide Dismutase, Catalase, Nitic oxide and Glutathione] were analyzed in these subjects. Results: DMPA, NET-EN and COCs treatment could induce oxidative stress with a significant change in lipid profile and other biochemical markers thus affecting the normal biological system. These effects after prolonged use can generate pathological events leading to disease pattern. Conclusion: These biomarkers can become diagnostic tools to evaluate the health of a woman using these methods as preventive measure in there